A co-delivery nanoplatform for a lignan-derived compound and perfluorocarbon tuning IL-25 secretion and the oxygen level in tumor microenvironments for meliorative tumor radiotherapy

Author:

Duan Zhenyu1,Luo Qiang1,Gu Lei1,Li Xiaoling1,Zhu Hongyan1,Gu Zhongwei1ORCID,Gong Qiyong12,Zhang Hu3,Luo Kui12ORCID

Affiliation:

1. Laboratory of Stem Cell Biology, and Huaxi MR Research Center (HMRRC), Department of Radiology, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China

2. Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, and Functional and molecular imaging Key Laboratory of Sichuan Province, Chengdu, 610041, China

3. Amgen Bioprocessing Centre, Keck Graduate Institute, Claremont, CA 91711, USA

Abstract

A co-delivery nanoplatform for a lignan-derived compound and perfluorocarbon was reported to increase the oxygen level and IL-25 secretion, providing a new strategy of manipulating the tumor microenvironment to improve the radiotherapeutics.

Funder

West China Hospital, Sichuan University

China Postdoctoral Science Foundation

National Natural Science Foundation of China

Department of Science and Technology of Sichuan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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