Unveiling the anti-inflammatory potential of 11β,13-dihydrolactucin for application in inflammatory bowel disease management

Author:

Matos Melanie S.12ORCID,Ávila-Gálvez María Ángeles13,González-Sarrías Antonio4ORCID,Silva Nuno-Valério3,Crespo Carolina Lage3ORCID,Jacinto António35ORCID,Serra Ana Teresa12,Matias Ana A.1,Nunes dos Santos Cláudia1235ORCID

Affiliation:

1. Instituto de Biologia Experimental e Tecnológica (iBET), 2780-157 Oeiras, Portugal

2. Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa (ITQB-NOVA), 2780-157 Oeiras, Portugal

3. NOVA Medical School, Faculdade de Ciências Médicas, NMS|FCM, Universidade Nova de Lisboa, 1169-056 Lisboa, Portugal

4. Laboratory of Food & Health, Research Group on Quality, Safety and Bioactivity of Plant Foods, CEBAS-CSIC, 30100 Campus de Espinardo, Murcia, Spain

5. NOVA Institute for Medical Systems Biology, NIMSB, Universidade Nova de Lisboa, 1099-085 Lisboa, Portugal

Abstract

11β,13-Dihydrolactucin, a sesquiterpene lactone found in chicory, presents promising anti-inflammatory potential in complementary in vitro and in vivo models of intestinal inflammation, acting at several levels of the cellular inflammatory response.

Funder

Horizon 2020 Framework Programme

Fundação para a Ciência e a Tecnologia

European Commission

Publisher

Royal Society of Chemistry (RSC)

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