A straightforward approach to antibodies recognising cancer specific glycopeptidic neoepitopes-Reference-Cited by-同舟云学术

A straightforward approach to antibodies recognising cancer specific glycopeptidic neoepitopes

Published:2020 Issue:19 Volume:11 Page:4999-5006
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Wakui Hajime¹²³⁴⁵,Tanaka Yoshikazu⁶⁷⁸⁹,Ose Toyoyuki¹⁰²³⁴¹¹,Matsumoto Isamu¹⁰²³⁴¹¹,Kato Koji¹²¹³¹⁴⁹,Min Yao¹⁰²³⁴¹¹,Tachibana Taro¹⁵¹⁶¹⁷¹⁸⁹,Sato Masaharu¹⁹²⁰⁹,Naruchi Kentaro¹⁹²⁰⁹,Martin Fayna Garcia¹²³⁴⁵,Hinou Hiroshi¹²³⁴⁵,Nishimura Shin-Ichiro¹²³⁴⁵^ORCID

Affiliation:

1. Field of Drug Discovery Research

2. Faculty of Advanced Life Science

3. Graduate School of Life Science

4. Hokkaido University

5. Sapporo

6. Graduate School of Life Sciences

7. Tohoku University

8. Sendai 980-8577

9. Japan

10. Field of X-ray Structural Biology

11. Sapporo 060-0810

12. Research Institute for Interdisciplinary Science and Graduate School of Natural Science and Technology

13. Okayama University

14. Okayama 700-8530

15. Department of Bioengineering

16. Graduate School of Engineering

17. Osaka City University

18. Osaka 558-8585

19. Medicinal Chemistry Pharmaceuticals, Co., Ltd.

20. Sapporo 060-0009

Abstract

We developed new class of designated antibodies targeting of “dynamic neoepitopes” elaborated by disease-specific O-glycosylation at the immunodominant mucin domains.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/D0SC00317D

Reference59 articles.

1. The Prioritization of Cancer Antigens: A National Cancer Institute Pilot Project for the Acceleration of Translational Research

2. MUC1: a multifaceted oncoprotein with a key role in cancer progression

3. Simple Sugars to Complex Disease—Mucin-Type O-Glycans in Cancer