Site-selective Suzuki–Miyaura coupling of heteroaryl halides – understanding the trends for pharmaceutically important classes-Reference-Cited by-同舟云学术

Site-selective Suzuki–Miyaura coupling of heteroaryl halides – understanding the trends for pharmaceutically important classes

Published:2017 Issue:1 Volume:8 Page:40-62
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Almond-Thynne Joshua¹²³⁴,Blakemore David C.⁵⁶⁴,Pryde David C.⁵⁶⁴,Spivey Alan C.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. Imperial College London

3. London

4. UK

5. Pfizer Worldwide Medicinal Chemistry

6. Cambridge

Abstract

Suzuki–Miyaura cross-coupling reactions of heteroaryl polyhalides with aryl boronates are surveyed. Drawing on data from literature sources and Pfizer's global chemistry RKB and CAS Scifinder® databases, factors that determine the site-selectivity of these reactions are discussed with a view to rationalising the trends.

Funder

Pfizer

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/SC/C6SC02118B

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