Interaction mechanism exploration of R-bicalutamide/S-1 with WT/W741L AR using molecular dynamics simulations-Reference-Cited by-同舟云学术

Interaction mechanism exploration of R-bicalutamide/S-1 with WT/W741L AR using molecular dynamics simulations

Published:2015 Issue:12 Volume:11 Page:3347-3354
ISSN:1742-206X
Container-title:Molecular BioSystems
language:en
Short-container-title:Mol. BioSyst.

Author:

Liu Hongli¹²³⁴,An Xiaoli¹²³⁴,Li Shuyan⁵²³⁴,Wang Yuwei¹²³⁴,Li Jiazhong¹²³⁴⁶,Liu Huanxiang¹²³⁴

Affiliation:

1. School of Pharmacy

2. Lanzhou University

3. 730000 Lanzhou

4. China

5. College of Chemistry and Chemical Engineering

6. The Separating Scientific Institute of Lanzhou

Abstract

R-Bicalutamide is a first generation antiandrogen used to treat prostate cancer, which inhibits androgen action by competitively binding to the androgen receptor (AR).

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MB/C5MB00499C

Reference53 articles.

1. Molecular Genetics and Epidemiology of Prostate Carcinoma

2. Cancer statistics, 2015

3. Cancer treatment and survivorship statistics, 2014

4. Chemistry and Structural Biology of Androgen Receptor

5. Nonsteroidal Selective Androgen Receptor Modulators (SARMs): Dissociating the Anabolic and Androgenic Activities of the Androgen Receptor for Therapeutic Benefit

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