Ruffling drives coproheme decarboxylation by facilitating PCET: a theoretical investigation of ChdC-Reference-Cited by-同舟云学术

Ruffling drives coproheme decarboxylation by facilitating PCET: a theoretical investigation of ChdC

Published:2020 Issue:28 Volume:22 Page:16117-16124
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Zhang Ying¹²³⁴⁵^ORCID,Wang Junkai¹²³⁴⁵,Yuan Chang¹²³⁴⁵^ORCID,Liu Wei¹²³⁴⁵,Tan Hongwei¹²³⁴⁵^ORCID,Li Xichen¹²³⁴⁵^ORCID,Chen Guangju¹²³⁴⁵

Affiliation:

1. Key Laboratory of Theoretical and Computational Photochemistry

2. College of Chemistry

3. Beijing Normal University

4. Beijing 100875

5. China

Abstract

Coproheme decarboxylase (ChdC) is an essential enzyme in the coproporphyrin-dependent heme synthesis pathway, which catalyzes oxidative decarboxylation of coproheme at the positions p2 and p4 to generate heme b under the action of hydrogen peroxide.

Funder

National Natural Science Foundation of China

National Basic Research Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CP/D0CP02690E

Reference45 articles.

1. Cell Biology of Heme

2. Enzymes of heme biosynthesis

3. Structure and function of enzymes in heme biosynthesis

4. Molecular hijacking of siroheme for the synthesis of heme and d1 heme

5. Making and breaking heme

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