Metabolic profiling of rats poisoned with paraquat and treated with Xuebijing using a UPLC-QTOF-MS/MS metabolomics approach-Reference-Cited by-同舟云学术

Metabolic profiling of rats poisoned with paraquat and treated with Xuebijing using a UPLC-QTOF-MS/MS metabolomics approach

Published:2020 Issue:37 Volume:12 Page:4562-4571
ISSN:1759-9660
Container-title:Analytical Methods
language:en
Short-container-title:Anal. Methods

Author:

Liu Wen¹²³⁴¹^ORCID,Li Sha¹⁵³⁴¹,Wu Yang Ke¹⁵³⁴,Yan Xiao¹²³⁴⁶,Zhu Yi Ming⁶³⁴,Jiang Fei Ya¹⁵³⁴,Jiang Yu⁶³⁴,Zou Liang Hong⁶³⁴,Wang Tong Tong¹⁵³⁴

Affiliation:

1. Department of Pharmacy

2. Hunan Provincial People's Hospital/The First Affiliated Hospital of Hunan Normal University

3. Changsha

4. China

5. Medical School of Hunan Normal University

6. Hunan Provincial Key Laboratory of Emergency and Critical Care Metabonomics

Abstract

In this study, we used an UPLC-QTOF-MS/MS metabolomics approach combined with pattern recognition, cluster analysis, and metabolic pathway analyses to investigate changes in metabolite levels in SD rats poisoned with PQ and subsequently treated with XBJ or left untreated.

Funder

Health and Family Planning Commission of Hunan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/AY/D0AY00968G

Reference36 articles.

1. Identification of the major constituents in Xuebijing injection by HPLC-ESI-MS

2. Xuebijing in the treatment of patients with sepsis

3. Prediction of outcome after paraquat poisoning by measurement of the plasma paraquat concentration