Crystal structure of a DNA duplex cross-linked by 6-thioguanine–6-thioguanine disulfides: reversible formation and cleavage catalyzed by Cu(ii) ions and glutathione

Author:

Ono Akira12345ORCID,Atsugi Takahiro12345,Goto Misato12345,Saneyoshi Hisao12345,Tomori Takahito6785,Seio Kohji6785,Dairaku Takenori910115,Kondo Jiro121314155

Affiliation:

1. Department of Materials & Life Chemistry

2. Faculty of Engineering

3. Kanagawa University

4. Yokohama

5. Japan

6. School of Life Science and Technology

7. Tokyo Institute of Technology

8. Yokohama 226-8501

9. School of Pharmaceutical Sciences

10. Ohu University

11. Koriyama

12. Department of Materials and Life Sciences

13. Faculty of Science and Technology

14. Sophia University

15. Tokyo 102-8554

Abstract

The crystal structure of a DNA duplex cross-linked by 6-thioguanine–6-thioguanine disulfides has been solved.

Funder

Ministry of Education, Culture, Sports, Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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