Binding symmetric porphyrins to the c-MYC promoter Pu24I G-quadruplex: toward more specific ligand recognition by flanking bases-Reference-Cited by-同舟云学术

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Binding symmetric porphyrins to the c-MYC promoter Pu24I G-quadruplex: toward more specific ligand recognition by flanking bases

Published:2023 Issue:23 Volume:47 Page:11176-11187
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Stanković Ivana¹,Zrilić Sonja²,Milovanović Branislav³^ORCID,Stanojević Ana³,Petković Milena³^ORCID,Etinski Mihajlo³^ORCID

Affiliation:

1. Institute of Chemistry, Technology and Metallurgy, Njegoševa 12, 11000 Belgrade, Serbia

2. Innovation Center of the Faculty of Chemistry, Studentski trg 12-16, 11158 Belgrade, Serbia

3. University of Belgrade—Faculty of Physical Chemistry, Studentski trg 12-16, 11158 Belgrade, Serbia

Abstract

The symmetric cationic porphyrin derivative TPyP4 exhibits higher selectivity toward flanking nucleotides of the c-MYC promoter G-quadruplex Pu24I than TMPyP4.

Funder

European Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NJ/D3NJ00956D

Reference64 articles.

1. Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics

2. Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription

3. A hitchhiker's guide to G-quadruplex ligands

4. DNA G-Quadruplex in Human Telomeres and Oncogene Promoters: Structures, Functions, and Small Molecule Targeting

5. Ligand Design to Acquire Specificity to Intended G-Quadruplex Structures

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