Binding symmetric porphyrins to the c-MYC promoter Pu24I G-quadruplex: toward more specific ligand recognition by flanking bases

Author:

Stanković Ivana1,Zrilić Sonja2,Milovanović Branislav3ORCID,Stanojević Ana3,Petković Milena3ORCID,Etinski Mihajlo3ORCID

Affiliation:

1. Institute of Chemistry, Technology and Metallurgy, Njegoševa 12, 11000 Belgrade, Serbia

2. Innovation Center of the Faculty of Chemistry, Studentski trg 12-16, 11158 Belgrade, Serbia

3. University of Belgrade—Faculty of Physical Chemistry, Studentski trg 12-16, 11158 Belgrade, Serbia

Abstract

The symmetric cationic porphyrin derivative TPyP4 exhibits higher selectivity toward flanking nucleotides of the c-MYC promoter G-quadruplex Pu24I than TMPyP4.

Funder

European Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

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