Metabolism and hydrophilicity of the polarised ‘Janus face’ all-cis tetrafluorocyclohexyl ring, a candidate motif for drug discovery-Reference-Cited by-同舟云学术

Metabolism and hydrophilicity of the polarised ‘Janus face’ all-cis tetrafluorocyclohexyl ring, a candidate motif for drug discovery

Published:2018 Issue:11 Volume:9 Page:3023-3028
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Rodil Andrea¹²³,Bosisio Stefano¹⁴⁵³,Ayoup Mohammed Salah¹²³⁶⁷,Quinn Laura⁸⁹¹⁰¹¹,Cordes David B.¹²³^ORCID,Slawin Alexandra M. Z.¹²³^ORCID,Murphy Cormac D.⁸⁹¹⁰¹¹,Michel Julien¹⁴⁵³,O'Hagan David¹²³^ORCID

Affiliation:

1. EaStChem School of Chemistry

2. University of St Andrews

3. UK

4. University of Edinburgh

5. Edinburgh

6. Department of Chemistry

7. Faculty of Science

8. UCD School of Biomolecular and Biomedical Sciences

9. University College Dublin

10. Dublin

11. Ireland

Abstract

The metabolism and polarity of the all-cis tetra-fluorocyclohexane motif is explored in the context of its potential as a motif for inclusion in drug discovery programmes.

Funder

European Research Council

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/SC/C8SC00299A

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