Phototriggerable peptidomimetics for the inhibition of Mycobacterium tuberculosis ribonucleotide reductase by targeting protein

Phototriggerable peptidomimetics for the inhibition of Mycobacterium tuberculosis ribonucleotide reductase by targeting protein–protein binding

Published:2015 Issue:9 Volume:13 Page:2612-2621
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Karlsson Christoffer¹²³⁴,Blom Magnus¹²³⁴,Johansson (neé Varedian) Miranda¹²³⁴,Jansson Anna M.⁵⁶²⁷⁴,Scifo Enzo⁵⁶²⁷⁴,Karlén Anders⁸⁹²³⁴,Govender Thavendran¹⁰¹¹¹²¹³,Gogoll Adolf¹²³⁴

Affiliation:

1. Department of Chemistry – BMC

2. Uppsala University

3. S-751 23 Uppsala

4. Sweden

5. Department of Cell and Molecular Biology

6. Structural Biology

7. S-751 24 Uppsala

8. Department of Medicinal Chemistry

9. Organic Pharmaceutical Chemistry

10. Catalysis and Peptide Research Unit

11. University of KwaZulu Natal

12. Durban 4000

13. South Africa

Abstract

Peptidomimetic inhibitors with photomodulable affinity for the R1–R2 subunit association site were designed based on the R2-subunit C-terminal.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C4OB01926A

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