Bleomycin-induced trans lipid formation in cell membranes and in liposome models-Reference-Cited by-同舟云学术

Bleomycin-induced trans lipid formation in cell membranes and in liposome models

Published:2015 Issue:4 Volume:13 Page:1100-1105
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Cort Aysegul¹²³⁴⁵,Ozben Tomris¹²³⁴⁵,Sansone Anna⁶⁷⁸⁹,Barata-Vallejo Sebastian⁶⁷⁸⁹¹⁰,Chatgilialoglu Chryssostomos¹¹¹²¹³¹⁴,Ferreri Carla⁶⁷⁸⁹

Affiliation:

1. Akdeniz University Medical Faculty

2. Department of Biochemistry

3. Dumlupinar Bulvari Campus

4. 07070 Antalya

5. Turkey

6. Institute for the Organic Synthesis and Photoreactivity

7. Consiglio Nazionale delle Ricerche

8. 40129 Bologna

9. Italy

10. Departamento de Química Orgánica

11. Institute of Nanoscience and Nanotechnology

12. National Center for Scientific Research “Demokritos”

13. Athens

14. Greece

Abstract

Bleomycin–iron complexes cause lipidcis–transisomerisation through thiyl radical formation and reactivity with unsaturated phospholipids, revealing membranes as a relevant and novel site of drug effect.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C4OB01924E

Reference26 articles.

1. Bleomycins: towards better therapeutics

2. Bleomycin: New Perspectives on the Mechanism of Action

3. On the mechanism of lipoxygenase-like action of bleomycin-iron complexes.

4. The production of hydroxyl radical by bleomycin and iron (II)

5. Definition of the intermediates and mechanism of the anticancer drug bleomycin using nuclear resonance vibrational spectroscopy and related methods

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