The acidic hydrolysis of N-acetylneuraminic 4,5-oxazoline allows a direct functionalization of the C5 position of Neu5Ac2en (DANA)-Reference-Cited by-同舟云学术

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The acidic hydrolysis of N-acetylneuraminic 4,5-oxazoline allows a direct functionalization of the C5 position of Neu5Ac2en (DANA)

Published:2020 Issue:1 Volume:10 Page:162-165
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Rota Paola¹²³⁴^ORCID,La Rocca Paolo⁵²³⁴,Cirillo Federica⁶⁷³⁴,Piccoli Marco⁶⁷³⁴,Allevi Pietro¹²³⁴,Anastasia Luigi⁶⁷³⁴⁸

Affiliation:

1. Department of Biomedical, Surgical and Dental Sciences

2. University of Milan

3. Milan

4. Italy

5. Department of Biomedical Sciences for Health

6. Laboratory of Stem Cells for Tissue Engineering

7. IRCCS Policlinico San Donato, San Donato Milanese

8. University of Vita-Salute San Raffaele

Abstract

The Neu5Ac 4,5-oxazoline ring-opening allows the direct generation of a free C5-amino group key to synthesize antiviral drugs.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RA/C9RA10215A

Reference24 articles.

1. Exploring Human Parainfluenza Virus Type-1 Hemagglutinin–Neuraminidase as a Target for Inhibitor Discovery

2. Potent Inhibitors against Newcastle Disease Virus Hemagglutinin-Neuraminidase

3. Synthesis and chemical characterization of several perfluorinated sialic acid glycals and evaluation of their in vitro antiviral activity against Newcastle disease virus

4. Structure-guided discovery of potent and dual-acting human parainfluenza virus haemagglutinin–neuraminidase inhibitors

5. The Catalytic Mechanism of Human Parainfluenza Virus Type 3 Haemagglutinin-Neuraminidase Revealed

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1. Interplay of Modified Sialic Acid Inhibitors and the Human Parainfluenza Virus 1 Hemagglutinin-Neuraminidase Active Site;ACS Medicinal Chemistry Letters;2023-09-26

2. Analysis of the intramolecular 1,7-lactone of N-acetylneuraminic acid using HPLC–MS: relationship between detection and stability;Glycoconjugate Journal;2023-04-21

3. Design, Synthesis, and Antiviral Evaluation of Sialic Acid Derivatives as Inhibitors of Newcastle Disease Virus Hemagglutinin-Neuraminidase: A Translational Study on Human Parainfluenza Viruses;ACS Infectious Diseases;2023-02-27

4. In Tandem Enantioselective Intramolecular Heck‐Matsuda Reactions directly from Anilines;Advanced Synthesis & Catalysis;2023-01-11

5. Oxazoline scaffold in synthesis of benzosiloxaboroles and related ring-expanded heterocycles: diverse reactivity, structural peculiarities and antimicrobial activity;RSC Advances;2022

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