Optimization of precision nanofiber micelleplexes for DNA delivery

Author:

Street Steven T. G.123ORCID,Parkin Hayley C.23ORCID,Shopperly Lennard45ORCID,Chrenek Josie45ORCID,Letwin Keiran45,Willerth Stephanie M.345ORCID,Manners Ian23ORCID

Affiliation:

1. School of Chemistry, University of Bristol, Bristol BS8 1TS, UK

2. Department of Chemistry, University of Victoria, Victoria, BC V8W 3V6, Canada

3. Centre for Advanced Materials and Related Technology (CAMTEC), University of Victoria, 3800 Finnerty Rd, Victoria, BC, V8P 5C2, Canada

4. Department of Mechanical Engineering, Division of Medical Sciences, University of Victoria, Victoria, BC V8W 2Y2, Canada

5. School of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z4, Canada

Abstract

Several factors important for understanding the formation and biological activity of nanofiber micelleplexes are examined and optimized in this work. These studies should inform the future design of more advanced polymeric DNA delivery systems.

Funder

University of Victoria

Canada Foundation for Innovation

British Columbia Knowledge Development Fund

Canada Research Chairs

Natural Sciences and Engineering Research Council of Canada

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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