Palladium-catalyzed cross-coupling of unactivated alkylzinc reagents with 2-bromo-3,3,3-trifluoropropene and its application in the synthesis of fluorinated amino acids-Reference-Cited by-同舟云学术

Palladium-catalyzed cross-coupling of unactivated alkylzinc reagents with 2-bromo-3,3,3-trifluoropropene and its application in the synthesis of fluorinated amino acids

Published:2019 Issue:26 Volume:55 Page:3705-3708
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Lou Yue-Guang¹²³⁴⁵,Wang An-Jun¹²³⁴⁵,Zhao Liang¹²³⁴⁵,He Lin-Feng¹²³⁴⁵,Li Xiao-Fei¹²³⁴⁵,He Chun-Yang¹²³⁴⁵^ORCID,Zhang Xingang⁶⁷⁸⁹¹⁰^ORCID

Affiliation:

1. Generic Drug Research Center of Guizhou Province

2. School of Pharmacy

3. Zunyi Medical University

4. Zunyi

5. P. R. China

6. Key Laboratory of Organofluorine Chemistry

7. Center for Excellence in Molecular Synthesis

8. Shanghai Institute of Organic Chemistry

9. Chinese Academy of Sciences

10. Shanghai 200032

Abstract

A palladium-catalyzed cross-coupling of unactivated alkylzinc reagents with 2-bromo-3,3,3-trifluoropropene (BTP) has been developed, which was used as a key step to prepare a series of trifluoromethylated and difluoromethylated amino acids.

Funder

National Natural Science Foundation of China

Chinese Academy of Sciences

China Association for Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CC/C8CC10212K

Reference38 articles.

1. Fluorine in Pharmaceuticals: Looking Beyond Intuition

2. 18F-Labeling of Arenes and Heteroarenes for Applications in Positron Emission Tomography

3. Fruitful Adrenergic α2C-Agonism/α2A-Antagonism Combination to Prevent and Contrast Morphine Tolerance and Dependence,

4. Fluorinated Proteins: From Design and Synthesis to Structure and Stability

5. Exploring and Exploiting Polar−π Interactions with Fluorinated Aromatic Amino Acids

Cited by 29 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. An experimental and theoretical study on the molecular interactions of N-aromatic L-proline in the condensed phase;Journal of Molecular Structure;2024-08

2. Palladium-Catalyzed Cross-Coupling of Heteroaryl Bromides with gem-Difluoroallylborons;Acta Chimica Sinica;2024

3. Catalyst-free decarboxylative cross-coupling of N-hydroxyphthalimide esters with tert-butyl 2-(trifluoromethyl)acrylate and its application;Organic & Biomolecular Chemistry;2024

4. Nickel‐Catalyzed Selective C(sp²)−F Bond Alkylation of Industrially Relevant Hydrofluoroolefin HFO‐1234yf;Angewandte Chemie International Edition;2023-08

5. Nickel‐Catalyzed Selective C(sp²)−F Bond Alkylation of Industrially Relevant Hydrofluoroolefin HFO‐1234yf;Angewandte Chemie;2023-08