Synthesis of skeletally diverse β-lactam haptens for the <i>in vitro</i> diagnosis of IgE-mediated drug allergy-Reference-Cited by-同舟云学术

Synthesis of skeletally diverse β-lactam haptens for the in vitro diagnosis of IgE-mediated drug allergy

Published:2022 Issue:40 Volume:58 Page:5964-5967
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Peña-Mendizabal Edurne¹,Hua Bruce K.²³,Ibañez-Echevarria Ethel⁴,de Rojas Dolores Hernández-Fernández⁵,Maquieira Ángel¹⁶⁷,Schreiber Stuart L.²³,Morais Sergi¹⁶⁷^ORCID

Affiliation:

1. IDM, Universitat Politècnica de València-Universitat de València, Camino de vera s/n, 46022 Valencia, Spain

2. Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, 02138, USA

3. Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, Massachusetts, 02142, USA

4. Hospital Universitari i Politènic La Fe, Servicio de Alergia, Avinguda de Fernando Abril Martorell, 106, 46026 València, Spain

5. Allergy Therapeutics Ibérica, Avda Barcelona, 115, Edificio Brasol, 2a planta, 08970 Sant Joan Despí, Barcelona, Spain

6. Departamento de Química, Universitat Politècnica de València, Camino de Vera s/n, 46022, Valencia, Spain

7. Unidad Mixta UPV-La Fe, Nanomedicine and Sensors, IIS La Fe, Valencia, Spain

Abstract

Skeletally diverse compounds derived from β-lactam antibiotics were synthesized to generate antigens for the in vitro diagnosis of IgE-mediated allergy.

Funder

Agencia Estatal de Investigación

Generalitat Valenciana

National Institute of General Medical Sciences

Ministerio de Educación, Cultura y Deporte

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D2CC01677J

Reference11 articles.

1. Skin test concentrations for systemically administered drugs - an ENDA/EAACI Drug Allergy Interest Group position paper

2. Multiplexed analytical approaches to beta-lactam allergy in vitro testing standardization

3. Boosting the sensitivity of in vitro β-lactam allergy diagnostic tests

4. Recent patents in allergy and immunology: New pyrazinones for the diagnosis of allergies to aminocephalosporins

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