Prdx6-induced inhibition of ferroptosis in epithelial cells contributes to liquiritin-exerted alleviation of colitis

Author:

Liu Jinming1,Sun Liqun2,Chen Dapeng3ORCID,Huo Xiaokui4ORCID,Tian Xiangge5ORCID,Li Juan1,Liu Min2,Yu Zhenlong46,Zhang Baojing6,Yang Yuewen3,Qiu Yang1,Liu Yuejian1,Guo Huishu1,Zhou Changjiang2,Ma Xiaochi4ORCID,Xiong Yongjian17ORCID

Affiliation:

1. Central Laboratory, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, P.R.China

2. Division of Gastroenterology, Dalian University Affiliated Xinhua Hospital, Dalian, 116021, P.R.China

3. Laboratory Animal Center, Dalian Medical University, Dalian, 116000, P.R.China

4. Pharmaceutical Research Center, Second Affiliated Hospital, Dalian Medical University, Dalian, 116023, P.R.China

5. Department of Pharmacy, Shenzhen Hospital of Peking University, Shenzhen, 518034, P.R.China

6. College of Pharmacy, Dalian Medical University, Dalian, 116051, P.R.China

7. College of Integrative Medicine, Dalian Medical University, Dalian, 116051, P.R.China

Abstract

Inhibition of ferroptosis in intestinal epithelial cells ameliorates clinical symptoms and improves endoscopic presentations in inflammatory bowel disease (IBD).

Funder

China Postdoctoral Science Foundation

Distinguished Professor of Liaoning Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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