Biosynthesis of natural products containing β-amino acids
Author:
Affiliation:
1. Department of Chemistry
2. Tokyo Institute of Technology
3. Tokyo 152-8551, Japan
4. Department of Chemistry and Materials Science
Abstract
β-Amino acids are unique components involved in a wide variety of natural products such as anticancer agents taxol, bleomycin, cytotoxic microcystin, enediyne compound C-1027 chromophore, nucleoside antibiotic blasticidin S, and macrolactam antibiotic vicenistatin. The biosynthesis and incorporation mechanisms are reviewed.
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2014/NP/C4NP00007B
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