Glycocalix[4]arenes and their affinity to a library of galectins: the linker matters-Reference-Cited by-同舟云学术

Glycocalix[4]arenes and their affinity to a library of galectins: the linker matters

Published:2023 Issue:6 Volume:21 Page:1294-1302
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Konvalinková Dorota¹,Dolníček František²,Hovorková Michaela¹³,Červený Jakub¹⁴,Kundrát Ondřej²,Pelantová Helena¹,Petrásková Lucie¹,Cvačka Josef⁵^ORCID,Faizulina Margarita²,Varghese Beena²,Kovaříček Petr²^ORCID,Křen Vladimír¹^ORCID,Lhoták Pavel²,Bojarová Pavla¹⁶^ORCID

Affiliation:

1. Institute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, CZ-14220 Prague 4, Czech Republic

2. Department of Organic Chemistry, University of Chemistry and Technology Prague, Technická 5, CZ-16628 Praha 6, Czech Republic

3. Department of Genetics and Microbiology, Faculty of Science, Charles University, Viničná 5, CZ-12843 Prague 2, Czech Republic

4. Department of Analytical Chemistry, Faculty of Science, Charles University, Hlavova 8, CZ-12843 Prague 2, Czech Republic

5. Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, CZ-166 10 Prague 6, Czech Republic

6. Department of Health Care Disciplines and Population Protection, Faculty of Biomedical Engineering, Czech Technical University in Prague, nám. Sítná 3105, CZ-272 01 Kladno, Czech Republic

Abstract

Glycocalix[4]arene ligands were prepared that had nanomolar affinity to galectins and induced their supramolecular aggregation. Lactose linkers and core conformations differed in their effect on galectin binding.

Funder

Ministerstvo Školství, Mládeže a Tělovýchovy

Nadace Experientia

Grantová Agentura České Republiky

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D2OB02235D

Reference46 articles.

1. Expression, Regulation, and Functions of the Galectin-16 Gene in Human Cells and Tissues