In vitro evidence of oncofetal antigen and TLR-9 agonist co-delivery by alginate nanovaccines for liver cancer immunotherapy

Author:

Pei Mengyue1,Li Huiyang1,Zhu Yingwei23,Lu Jian3,Zhang Chuangnian14ORCID

Affiliation:

1. Tianjin Key Laboratory of Biomaterial Research, Biomedical Barriers Research Center, Institute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, 300192, China

2. Department of Gastroenterology, The Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University, Wuxi city, 214002, China

3. Department of Gastroenterology, Wuxi No. 2 People's Hospital, Affiliated Wuxi Clinical College of Nantong University, Wuxi city, 214002, China

4. State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300353, China

Abstract

Antigen and adjuvant co-delivery nanovaccines were prepared to induce antigen-specific antitumor immune responses against liver cancer.

Funder

National Natural Science Foundation of China

State Key Laboratory of Medicinal Chemical Biology

Wuxi Health and Family Planning Commission

Peking Union Medical College

Chinese Academy of Medical Sciences Initiative for Innovative Medicine

Wuxi Municipal Bureau on Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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