Intracellular location matters: rationalization of the anti-inflammatory activity of a manganese(ii) superoxide dismutase mimic complex

Author:

Mathieu Emilie12345,Bernard Anne-Sophie12345,Quévrain Elodie12345,Zoumpoulaki Martha12345,Iriart Sébastien12345,Lung-Soong Caroline12345,Lai Barry6789,Medjoubi Kadda10111213,Henry Lucas12345,Nagarajan Sounderya141551617,Poyer Florent141551617,Scheitler Andreas18192021ORCID,Ivanović-Burmazović Ivana18192021,Marco Sergio141551617,Somogyi Andrea10111213ORCID,Seksik Philippe22452324,Delsuc Nicolas12345ORCID,Policar Clotilde12345ORCID

Affiliation:

1. Laboratoire des biomolécules

2. LBM

3. Département de chimie

4. Ecole normale supérieure

5. PSL University

6. X-ray Science Division

7. Argonne National Laboratory

8. Argonne

9. USA

10. Synchrotron SOLEIL

11. BP 48

12. 91192 Gif sur Yvette

13. France

14. Institut Curie

15. Research Center

16. Chemistry

17. Modelling and Imaging for Biology (CMIB)

18. Department of Chemistry and Pharmacy

19. University of Erlangen-Nürnberg

20. 91058 Erlangen

21. Germany

22. Sorbonne Université

23. CNRS

24. INSERM

Abstract

The study of Mn-based superoxide dismutase mimic conjugated with a multimodal Re-probe in a cellular model of oxidative stress revealed that its bioactivity is associated with its accumulation at the mitochondria.

Funder

Agence Nationale de la Recherche

Fondation pour la Recherche Médicale

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Reference48 articles.

1. Approaches to the design of catalytic metallodrugs

2. C. Policar , in Redox Active Therapeutics , ed. J. S. Reboucas , I. Batinic-Haberle , I. Spasojevic , D. S. Warner and D. S. Clair , Springer , 2016 , ch. 17, pp. 125–164

3. Manganese superoxide dismutase, MnSOD and its mimics

4. Superoxide Dismutase Mimetics

5. SOD Therapeutics: Latest Insights into Their Structure-Activity Relationships and Impact on the Cellular Redox-Based Signaling Pathways

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