3-Hydroxyflavone is a mildly active and safe cobalt chelator while cobalt markedly enhances baicalein toxicity toward erythrocytes-Reference-Cited by-同舟云学术

3-Hydroxyflavone is a mildly active and safe cobalt chelator while cobalt markedly enhances baicalein toxicity toward erythrocytes

Published:2023 Issue:42 Volume:13 Page:29242-29251
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Moravcová Monika¹^ORCID,Lomozová Zuzana²^ORCID,Kučera Radim³^ORCID,Mladěnka Přemysl¹^ORCID

Affiliation:

1. The Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Akademika Heyrovského 1203, 50005 Hradec Králové, Czech Republic

2. The Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmacy in Hradec Králové, Charles University, Akademika Heyrovského 1203, 50005 Hradec Králové, Czech Republic

3. The Department of Pharmaceutical Chemistry and Pharmaceutical Analysis, Faculty of Pharmacy in Hradec Králové, Charles University, Akademika Heyrovského 1203, 50005 Hradec Králové, Czech Republic

Abstract

Flavonoids were screened for chelation of Co2+ ions. The most active, 3-hydroxyflavone and baicalein, as well as inactive quercetin were further tested (the cobalt-triggered Fenton chemistry and erythrocyte lysis in the presence of cobalt ions).

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA02735J

Reference58 articles.

1. A review of the health hazards posed by cobalt

2. Cobalt toxicity in humans—A review of the potential sources and systemic health effects

3. Fatal cobalt toxicity after total hip arthroplasty revision for fractured ceramic components

4. Carcinogenic hazard assessment of cobalt-containing alloys in medical devices: Review of in vivo studies

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. HYDROXYFLAVONE COMPLEXES WITH BIOGENIC AND ABIOGENIC METALS;FARMACIA;2024

2. Comparative spectrophotometric determination of 3-hydroxyflavone based on zinc and aluminium complexes and their antioxidative profiles;Arhiv za farmaciju;2024