Size-tuneable and immunocompatible polymer nanocarriers for drug delivery in pancreatic cancer

Author:

Popov Andrea Bistrović1,Melle Francesca2,Linnane Emily2,González-López Cristina13,Ahmed Ishtiaq1,Parshad Badri1,Franck Christoph O.1,Rahmoune Hassan4,Richards Frances M.56ORCID,Muñoz-Espín Daniel3,Jodrell Duncan I.57,Fairen-Jimenez David2ORCID,Fruk Ljiljana1

Affiliation:

1. BioNano Engineering Lab, Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, UK

2. The Adsorption & Advanced Materials Laboratory (A2ML), Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, UK

3. CRUK Cambridge Centre Early Detection Program, Department of Oncology, Hutchison/MRC Research Centre, University of Cambridge, Cambridge CB2 0RE, UK

4. Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, UK

5. Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge CB2 0RE, UK

6. Translational Medicine, Oncology R&D, Astra Zeneca, Cambridge CB4 0WG, UK

7. Department of Oncology, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge, CB2 0XZ, UK

Abstract

Pluronic-polydopamine nanocarriers were used to evaluate the effect of particle size on immunocompatiblity and cell uptake in pancreatic cancer. The drug-loaded carriers exhibited enhanced antiproliferative effects in this hard-to-treat cancer.

Funder

University of Cambridge

Atlantic Philanthropies

Cancer Research UK

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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