Anti-androgenic potential of the fruit extracts of certain Egyptian Sabal species and their genetic variability studies: a metabolomic-molecular modeling approach

Author:

Abd Almaksoud Hanan M.1,El-Hawary Seham S.2,Atia Mohamed A. M.3,Sayed Ahmed M.4ORCID,El-Daly Mahmoud5ORCID,Kamel Amr Abdallah5,Elimam Hanan67ORCID,Abdelmohsen Usama Ramadan89ORCID,Saber Fatema R.2ORCID

Affiliation:

1. Department of Pharmacy, New Al Kaser Alini Hospital, Cairo, Egypt

2. Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt

3. Molecular Genetics and Genome Mapping Laboratory, Genome Mapping Department, Agricultural Genetic Engineering Research Institute (AGERI), Agricultural Research Center (ARC), Giza 12619, Egypt

4. Department of Pharmacognosy, Faculty of Pharmacy, Nahda University, Beni-Suef 62513, Egypt

5. Department of Pharmacology & Toxicology, Faculty of Pharmacy, Minia University, El-Minia 61519, Egypt

6. Department of Biochemistry, Faculty of Pharmacy, University of Sadat City, Sadat City 32897, Egypt

7. Department of Biochemistry, Faculty of Pharmacy, Sinai University, Kantara, Egypt

8. Department of Pharmacognosy, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

9. Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, Universities Zone, 61111 New Minia City, Minia, Egypt

Abstract

This paper investigates the metabolites of S. blackburniana, S. causiarum and S. palmetto fruit extracts as promising source of bioactive anti-androgenic metabolites and reports a remarkable anti-androgenic effect.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Reference71 articles.

1. L. H.Bailey and H.Third , A Concise Dictionary of Plants Cultivated in the United States and Canada , Staff of the L.H. Bailey Hortorium, Cornell University , 1976

2. E.Zeiger , Saw palmetto (Serenoa repens) and one of its constituent sterols β-sitosterol: review of toxicological literature, PhD of Medicine , North Carolina: National Institute of Environmental Health Sciences , Research Triangle Park , 1997

3. Inhibition of type 1 and type 2 5α-reductase activity by free fatty acids, active ingredients of Permixon®

4. J. D.Birkhoff , Benign prostatic hypertrophy , ed F. Hinman , Springer Verlag , New York , 1983

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