Synthesis of tetra-substituted 5-trifluoromethylpyrazoles via sequential halogenation/palladium-catalyzed C–C and C–N cross-coupling-Reference-Cited by-同舟云学术

Synthesis of tetra-substituted 5-trifluoromethylpyrazoles via sequential halogenation/palladium-catalyzed C–C and C–N cross-coupling

Published:2016 Issue:7 Volume:14 Page:2352-2359
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Wiethan Carson¹²³⁴,Rosa Wilian C.¹²³⁴,Bonacorso Helio G.¹²³⁴,Stradiotto Mark⁵⁶⁷

Affiliation:

1. Departamento de Química

2. Universidade Federal de Santa Maria

3. 97105-900 Santa Maria

4. Brazil

5. Department of Chemistry

6. Dalhousie University Halifax

7. B3H 4R2 Canada

Abstract

The assembly of tetra-substituted 5-trifluoromethylpyrazoles is presented, involving palladium-catalyzed Negishi or Buchwald–Hartwig cross-couplings to install carbon or nitrogen-based 4-substituents.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C5OB02390D

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