A solvent-dependent chirality-switchable thia-Michael addition to α,β-unsaturated carboxylic acids using a chiral multifunctional thiourea catalyst-Reference-Cited by-同舟云学术

A solvent-dependent chirality-switchable thia-Michael addition to α,β-unsaturated carboxylic acids using a chiral multifunctional thiourea catalyst

Published:2020 Issue:21 Volume:11 Page:5572-5576
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Hayama Noboru¹²³⁴⁵,Kobayashi Yusuke¹²³⁴^ORCID,Sekimoto Eriko⁵⁶⁷⁴,Miyazaki Anna⁵⁶⁷⁴,Inamoto Kiyofumi⁵⁶⁷⁴,Kimachi Tetsutaro⁵⁶⁷⁴,Takemoto Yoshiji¹²³⁴^ORCID

Affiliation:

1. Graduate School of Pharmaceutical Sciences

2. Kyoto University

3. Kyoto 606-8501

4. Japan

5. School of Pharmacy and Pharmaceutical Sciences

6. Mukogawa Women's University

7. Nishinomiya

Abstract

An asymmetric thia-Michael addition of arylthiols to α,β-unsaturated carboxylic acids using a thiourea catalyst that bears arylboronic acid and tertiary amine moieties is reported.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/D0SC01729A

Reference50 articles.

1. Asymmetric synthesis of tertiary thiols and thioethers

2. Organocatalytic Carbon–Sulfur Bond-Forming Reactions

3. Nanomolar Inhibitors for Two Distinct Biological Target Families from a Single Synthetic Sequence: A Next Step in Combinatorial Library Design?