Amplification of the chiroptical response of UV-transparent amines and alcohols by N-phthalimide derivatization enabling absolute configuration determination through ECD computational analysis

Author:

Padula Daniele1234ORCID,Mazzeo Giuseppe12345ORCID,Santoro Ernesto1234ORCID,Scafato Patrizia1234,Belviso Sandra1234ORCID,Superchi Stefano1234ORCID

Affiliation:

1. Dipartimento di Scienze

2. Università della Basilicata

3. Potenza

4. Italy

5. Dipartimento di Medicina Molecolare e Traslazionale

Abstract

Transformation of chiral UV-transparent amines and alcohols to phthalimides enhances their chiroptical response allowing their absolute configuration assignment by ECD computation.

Funder

Ministero dell’Istruzione, dell’Università e della Ricerca

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference71 articles.

1. Application of electronic circular dichroism in configurational and conformational analysis of organic compounds

2. Comprehensive Chiroptical Spectroscopy , ed. N. Berova , P. L. Polavarapu , K. Nakanishi and R. W. Woody , John Wiley & Sons, Inc. , Hoboken, NJ, USA , 2012 , vols. 1 and 2

3. N. Berova , G. A.Ellestad and N.Harada , in Comprehensive Natural Products II Chemistry and Biology , ed. L. Mander and H.-W. Lui , Elsevier , Oxford , 2010 , ch. 4, vol. 9 , pp. 91–146

4. S. Superchi , C.Rosini , G.Mazzeo and E.Giorgio , in Comprehensive Chiroptical Spectroscopy , ed. N. Berova , P. L. Polavarapu , K. Nakanishi and R. W. Woody , John Wiley & Sons, Inc. , Hoboken, NJ, USA , 2012 , ch. 12, vol. 2 , pp. 421–427

5. Renaissance in chiroptical spectroscopic methods for molecular structure determination

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