Novel thermoplastic microvalves based on an elastomeric cyclic olefin copolymer

Author:

Childers Katie12,Freed Ian M.23ORCID,Hupert Mateusz L.4,Shaw Benjamin25,Larsen Noah26,Herring Paul7,Norton Jeanne H.7,Shiri Farhad23,Vun Judy8,August Keith J.8,Witek Małgorzata A.23,Soper Steven A.123910ORCID

Affiliation:

1. Bioengineering Program, The University of Kansas, Lawrence, KS 66045, USA

2. Center of BioModular Multiscale Systems for Precision Medicine, The University of Kansas, Lawrence, KS 66045, USA

3. Department of Chemistry, The University of Kansas, Lawrence, KS 66045, USA

4. BioFluidica Inc., San Diego, CA 92121, USA

5. Department of Chemical Engineering, The University of Kansas, Lawrence, KS 66045, USA

6. Department of Engineering Physics, The University of Kansas, Lawrence, KS 66045, USA

7. Department of Plastics Engineering Technology, Pittsburg State University, Pittsburg, KS 66762, USA

8. Department of Pediatrics, Children's Mercy Hospital, Kansas City, MO 64108, USA

9. Department of Mechanical Engineering, The University of Kansas, Lawrence, KS 66045, USA

10. KU Cancer Center, University of Kansas Medical Center, Kansas City, KS 66160, USA

Abstract

We introduce cyclic olefin copolymer elastomer as a membrane layer for pneumatically or mechanically actuated microvalves using a simple bonding procedure and demonstrate its utility within a modular system for CLC isolation and immunophenotyping.

Funder

National Institutes of Health

National Cancer Institute

University of Kansas

Cancer Center, University of Kansas

Publisher

Royal Society of Chemistry (RSC)

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