ZnIIand HgIIbinding to a designed peptide that accommodates different coordination geometries

Author:

Szunyogh Dániel123,Gyurcsik Béla12345,Larsen Flemming H.6789,Stachura Monika101112,Thulstrup Peter W.137149,Hemmingsen Lars137149,Jancsó Attila12345

Affiliation:

1. MTA-SZTE Bioinorganic Chemistry Research Group

2. Szeged

3. Hungary

4. Department of Inorganic and Analytical Chemistry

5. University of Szeged

6. Department of Food Science

7. University of Copenhagen

8. 1958 Frederiksberg C

9. Denmark

10. CERN

11. 1211-Geneva

12. Switzerland

13. Department of Chemistry

14. 2100 Copenhagen

Abstract

Inspired by the metal ion binding loop of the MerR family of metalloregulatory proteins, a 12-mer peptide was designed with a broad metal ion specificity, allowing for both linear and tetrahedral coordination geometries.

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Reference83 articles.

1. Metal sensor proteins: nature's metalloregulated allosteric switches

2. Coordination Chemistry of Bacterial Metal Transport and Sensing

3. Metalloproteins and metal sensing

4. How do bacterial cells ensure that metalloproteins get the correct metal?

5. B. Zambelli , F.Musiani and S.Ciurli, Metal Ion-Mediated DNA-Protein Interactions in Interplay between Metal Ions and Nucleic Acids, Metal Ions in Life Sciences 10, ed. A. Sigel, H. Sigel and R. K. O. Sigel, Springer, Netherlands, 2012, pp. 135–170

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