New reduction pathways for ctc-[PtCl2(CH3CO2)2(NH3)(Am)] anticancer prodrugs-Reference-Cited by-同舟云学术

New reduction pathways for ctc-[PtCl2(CH3CO2)2(NH3)(Am)] anticancer prodrugs

Published:2010 Issue:11 Volume:46 Page:1842-1844
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Nemirovski Alina¹²³⁴⁵,Vinograd Inbal¹²³⁴⁵,Takrouri Khuloud¹²³⁴⁵,Mijovilovich Ana⁶⁷⁸⁹¹⁰,Rompel Annette¹¹¹²¹³¹⁴,Gibson Dan¹²³⁴⁵

Affiliation:

1. Department of Medicinal Chemistry and Natural Products

2. Institute of Drug Research

3. The Hebrew University of Jerusalem

4. Jerusalem 91120

5. Israel

6. Inorganic Chemistry and Catalysis Group

7. Department of Chemistry

8. Utrecht University

9. Utrecht

10. The Netherlands

11. Institut für Biophysikalische Chemie

12. Universität Wien

13. A-1090 Wien

14. Austria

Abstract

Reduction of anticancer prodrugs such as ctc-[PtCl₂(CH₃CO₂)₂(NH₃)(Am)] can yield three products in addition to the expected cis-[PtCl₂(NH₃)(Am)], by the loss of two axial ligands, one axial and one equatorial ligand, or two equatorial ligands.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2010/CC/B925721G

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