Conformational dynamics is critical for the allosteric inhibition of cGAS upon acetyl-mimic mutations-Reference-Cited by-同舟云学术

Conformational dynamics is critical for the allosteric inhibition of cGAS upon acetyl-mimic mutations

Published:2021 Issue:3 Volume:23 Page:2154-2165
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Guo Jingjing¹²³⁴^ORCID,Li Mengrong¹²³⁴,Zhang Yan⁵⁶⁷⁴,Xi Lili⁸⁹¹⁰⁴^ORCID,Cui Fengling¹¹¹²¹³⁴

Affiliation:

1. College of Life Sciences

2. Nanjing Agricultural University

3. Nanjing

4. China

5. Department of Pharmacy

6. Guizhou University of Traditional Chinese Medicine

7. Guiyang

8. Institution of Drug Clinical Trial

9. The First Hospital of Lanzhou University

10. Lanzhou

11. School of Chemistry and Chemical Engineering

12. Henan Normal University

13. Xinxiang 453007

Abstract

In the present study, the allosteric inhibition mechanism of cGAS upon acetyl-mimic mutations was investigated, and conformational dynamics was found to be especially critical.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CP/D0CP05871H

Reference53 articles.

1. Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

2. Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

3. The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling

4. STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

5. ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

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