Three-dimensional brain-on-a-chip with an interstitial level of flow and its application as an in vitro model of Alzheimer's disease-Reference-Cited by-同舟云学术

Three-dimensional brain-on-a-chip with an interstitial level of flow and its application as an in vitro model of Alzheimer's disease

Published:2015 Issue:1 Volume:15 Page:141-150
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Park JiSoo¹²³⁴,Lee Bo Kyeong⁵⁶²⁷⁴,Jeong Gi Seok⁵⁶²⁷⁴,Hyun Jung Keun⁸⁹⁴¹⁰¹¹,Lee C. Justin¹²³⁴¹²,Lee Sang-Hoon¹²³⁴⁵

Affiliation:

1. KU-KIST Graduate School of Converging Science and Technology

2. Korea University

3. Seoul 136-701

4. Republic of Korea

5. School of Biomedical Engineering

6. College of Health Science

7. Seoul 136-703

8. Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine

9. Institute of Tissue Regeneration Engineering (ITREN)

10. Department of Nanobiomedical Science

11. Dankook University

12. Center for Neuroscience

Abstract

In this paper, we developed a three-dimensional brain-on-a-chip with an interstitial level of flow. The chip contains an osmotic micropump system for providing interstitial flow and a concave microwell array for mimicking the brain's 3D cytoarchitecture.

Funder

Ministry of Education, Science and Technology

Ministry of Health and Welfare

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2015/LC/C4LC00962B

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