Construction of homogeneous antibody–drug conjugates using site-selective protein chemistry-Reference-Cited by-同舟云学术

Construction of homogeneous antibody–drug conjugates using site-selective protein chemistry

Published:2016 Issue:5 Volume:7 Page:2954-2963
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Akkapeddi Padma¹²³⁴⁵,Azizi Saara-Anne⁶⁷⁸⁹,Freedy Allyson M.⁶⁷⁸⁹,Cal Pedro M. S. D.¹²³⁴⁵,Gois Pedro M. P.¹⁰¹¹³¹²⁵,Bernardes Gonçalo J. L.¹²³⁴⁵

Affiliation:

1. Instituto de Medicina Molecular

2. Faculdade de Medicina

3. Universidade de Lisboa

4. 1649-028 Lisboa

5. Portugal

6. Department of Chemistry

7. University of Cambridge

8. CB2 1EW Cambridge

9. UK

10. Research Institute for Medicines (iMed.ULisboa)

11. Faculty of Pharmacy

12. Lisbon

Abstract

The use of site-selective chemical drug-conjugation strategies enables the construction of antibody–drug conjugates (ADCs) with superior therapeutic efficacy.”

Funder

Gates Cambridge Trust

European Commission

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/SC/C6SC00170J

Reference98 articles.

1. Antibody-Drug Conjugates in Cancer Therapy

2. Antibody-Drug Conjugates: An Emerging Concept in Cancer Therapy

3. Antibody Drug Conjugates for Cancer Therapy

4. The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma

5. Ado-trastuzumab Emtansine (T-DM1): An Antibody–Drug Conjugate (ADC) for HER2-Positive Breast Cancer

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