Enantioselective Pd-catalyzed dearomative reductive Heck and domino Heck–Suzuki reactions of 2-CF<sub>3</sub>-indoles-Reference-Cited by-同舟云学术

Enantioselective Pd-catalyzed dearomative reductive Heck and domino Heck–Suzuki reactions of 2-CF₃-indoles

Published:2022 Issue:42 Volume:58 Page:6200-6203
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Liang Ren-Xiao¹^ORCID,Chen Jian-Fei¹,Huang Ying-Ying¹,Yu Ya-Ping¹,Zhang Han-Yue¹,Song Yu-Feng¹,Tsui Gavin Chit²^ORCID,Jia Yi-Xia¹^ORCID

Affiliation:

1. College of Chemical Engineering, State Key Laboratory Breeding Base of Green Chemical Synthesis Technology, Zhejiang University of Technology, Chaowang Road 18#, Hangzhou, 310014, China

2. Department of Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong

Abstract

Highly enantioselective palladium-catalyzed dearomative reductive Heck and domino Heck–Suzuki reactions of 2-CF3-indoles have been developed towards the synthesis of indolines bearing trifluoromethyl quaternary stereocenters.

Funder

Chinese University of Hong Kong

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D2CC01435A

Reference36 articles.

1. Fluorine in Pharmaceuticals: Looking Beyond Intuition

2. Fluorine in medicinal chemistry

3. Fluorination in Medicinal Chemistry: Methods, Strategies, and Recent Developments

4. Stereoselective fluoroarylation of 1,1-difluoroallenes enabled by palladium catalysis

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