Small molecule binders recognize DNA microstructural variations via an induced fit mechanism
Author:
Affiliation:
1. Department of Chemistry and Center for Diagnostics and Therapeutics
2. Georgia State University
3. Atlanta
4. USA
5. Aflac Cancer and Blood Disorders Center
Abstract
Site-specific recognition through contacts, water displacement, and dynamics of a linked azabenzimidazole-diamidine within the DNA minor groove.
Funder
National Institute of General Medical Sciences
Publisher
Royal Society of Chemistry (RSC)
Subject
Physical and Theoretical Chemistry,General Physics and Astronomy
Link
http://pubs.rsc.org/en/content/articlepdf/2019/CP/C8CP05537H
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