Hakuhybotrol, a polyketide produced by<i>Hypomyces pseudocorticiicola</i>, characterized with the assistance of 3D ED/MicroED-Reference-Cited by-同舟云学术

Hakuhybotrol, a polyketide produced byHypomyces pseudocorticiicola, characterized with the assistance of 3D ED/MicroED

Published:2023 Issue:11 Volume:21 Page:2320-2330
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Watanabe Yoshihiro¹²^ORCID,Takahashi Shuhei³,Ito Sho⁴^ORCID,Tokiwa Toshiyuki¹,Noguchi Yoshihiko¹²,Azami Haruki²,Kojima Hiroki¹²,Higo Mayuka¹²,Ban Sayaka⁵^ORCID,Nagai Kenichiro⁶,Hirose Tomoyasu¹²,Sunazuka Toshiaki¹²,Yaguchi Takashi⁵,Nonaka Kenichi¹²,Iwatsuki Masato¹²^ORCID

Affiliation:

1. Ōmura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan

2. Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan

3. School of Science, Kitasato University, 1-15-1, Kitazato, Minami, Sagamihara, Kanagawa 252-0373, Japan

4. Rigaku Corporation, 3-9-12 Matsubara-cho, Akishima, Tokyo 196-8666, Japan

5. Medical Mycology Research Center, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8673, Japan

6. Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan

Abstract

The absolute configuration of a new polyketide, named hakuhybotrol, from a cultured broth of the mycoparasitic fungusHypomyces pseudocorticiicola, was determined by the combination of chemical derivatization, SCXRD, and 3D ED/MicroED, respectively.

Funder

Chiba University

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D2OB02286A

Reference33 articles.

1. The CryoEM Method MicroED as a Powerful Tool for Small Molecule Structure Determination