Identification and engineering of potent cyclic peptides with selective or promiscuous binding through biochemical profiling and bioinformatic data analysis-Reference-Cited by-同舟云学术

Identification and engineering of potent cyclic peptides with selective or promiscuous binding through biochemical profiling and bioinformatic data analysis

Published:2024 Issue:1 Volume:5 Page:12-18
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Smith Thomas P.¹^ORCID,Bhushan Bhaskar²^ORCID,Granata Daniele³,Kaas Christian S.⁴,Andersen Birgitte⁵,Decoene Klaas W.⁴^ORCID,Ren Qiansheng⁶,Liu Haimo⁶,Qu Xinping⁶,Yang Yang⁶,Pan Jia⁶,Chen Quijia⁶,Münzel Martin⁴^ORCID,Kawamura Akane¹²^ORCID

Affiliation:

1. Chemistry – School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK

2. Department of Chemistry, University of Oxford, OX1 3TA, UK

3. Digital Science and Innovation, Novo Nordisk A/S, Novo Nordisk Park, 2760 Måløv, Denmark

4. Global Research Technologies, Novo Nordisk A/S, Novo Nordisk Park, 2760 Måløv, Denmark

5. Global Drug Discovery, Novo Nordisk A/S, Novo Nordisk Park, 2760 Måløv, Denmark

6. Novo Nordisk Research Center China, Novo Nordisk A/S, Shengmingyuan West Ring Rd, Changping District, Beijing, China

Abstract

In this work different methods stemming from mRNA display were investigated toward developing potent binding cyclic peptides with distinct selectivity profiles against targets of a related protein family.

Funder

European Research Council

Novo Nordisk

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CB/D3CB00168G

Reference15 articles.

1. Macrocyclic Peptides as Drug Candidates: Recent Progress and Remaining Challenges