Next generation maleimides enable the controlled assembly of antibody–drug conjugates via native disulfide bond bridging-Reference-Cited by-同舟云学术

Next generation maleimides enable the controlled assembly of antibody–drug conjugates via native disulfide bond bridging

Published:2014 Issue:37 Volume:12 Page:7261-7269
ISSN:1477-0520
Container-title:Org. Biomol. Chem.
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Schumacher Felix F.¹²³,Nunes João P. M.¹²³,Maruani Antoine¹²³,Chudasama Vijay¹²³,Smith Mark E. B.¹²³,Chester Kerry A.⁴³,Baker James R.¹²³,Caddick Stephen¹²³

Affiliation:

1. Department of Chemistry

2. University College London

3. London, UK

4. UCL Cancer Institute

Abstract

Highly homogeneous ADCs are generated by the efficient bridging of interchain disulfide bonds in trastuzumab, using next generation maleimides.

Funder

Wellcome Trust

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/OB/C4OB01550A

Reference41 articles.

1. Paul Ehrlich's magic bullet concept: 100 years of progress

2. Synthesis and Evaluation of Hydrophilic Linkers for Antibody–Maytansinoid Conjugates

3. Antibody-drug conjugates

4. Antibody–drug conjugates: targeted drug delivery for cancer

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