Manipulation of a DNA aptamer–protein binding site through arylation of internal guanine residues-Reference-Cited by-同舟云学术

Manipulation of a DNA aptamer–protein binding site through arylation of internal guanine residues

Published:2018 Issue:20 Volume:16 Page:3831-3840
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Van Riesen Abigail J.¹²³⁴,Fadock Kaila L.¹²³⁴,Deore Prashant S.¹²³⁴,Desoky Ahmed¹²³⁴⁵,Manderville Richard A.¹²³⁴^ORCID,Sowlati-Hashjin Shahin⁶⁷⁸⁹,Wetmore Stacey D.⁶⁷⁸⁹^ORCID

Affiliation:

1. Department of Chemistry & Toxicology

2. University of Guelph

3. Guelph

4. Canada N1G 2W1

5. Department of Chemistry

6. Department of Chemistry & Biochemistry

7. University of Lethbridge

8. Lethbridge

9. Canada T1K 3M4

Abstract

Chemically modified aptamers have the opportunity to increase aptamer target binding affinity and provide structure–activity relationships to enhance our understanding of molecular target recognition by the aptamer fold.

Funder

Natural Sciences and Engineering Research Council of Canada

Canada Research Chairs

Canada Foundation for Innovation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB00704G

Reference32 articles.

1. In vitro selection of RNA molecules that bind specific ligands