Induction of apoptosis in MDA-MB-231 breast cancer cells by a PARP1-targeting PROTAC small molecule-Reference-Cited by-同舟云学术

Induction of apoptosis in MDA-MB-231 breast cancer cells by a PARP1-targeting PROTAC small molecule

Published:2019 Issue:3 Volume:55 Page:369-372
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Zhao Qiuye¹²³⁴⁵^ORCID,Lan Tianlong¹²³⁴⁵^ORCID,Su Shang¹⁶⁴⁵⁷^ORCID,Rao Yu¹²³⁴⁵^ORCID

Affiliation:

1. MOE Key Laboratory of Protein Sciences

2. School of Pharmaceutical Sciences

3. MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology

4. Tsinghua University

5. Beijing 100084

6. School of Life Sciences

7. P. R. China

Abstract

We report for the first time a PARP1-targeting PROTAC small molecule to selectively induce the cleavage of PARP1.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CC/C8CC07813K

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5. (ADP-ribose)n participates in DNA excision repair

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