The proteomic profiling of multiple tissue damage in chickens for a selenium deficiency biomarker discovery

Author:

Zhang Ziwei12345ORCID,Liu Qi1234,Yang Jie1234,Yao Haidong6789,Fan Ruifeng10111213ORCID,Cao Changyu14151613,Liu Ci17181913,Zhang Sheng20212223,Lei Xingen24212223,Xu Shiwen12345ORCID

Affiliation:

1. College of Veterinary Medicine

2. Northeast Agricultural University

3. Harbin 150030

4. PR China

5. Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment

6. Department of Biosciences and Nutrition

7. Karolinska Institute

8. Stockholm

9. Sweden

10. College of Animal Science and Veterinary Medicine

11. Shandong Agricultural University

12. Tai'an

13. P. R. China

14. College of Life and Science

15. Foshan University

16. Foshan

17. College of Animal Technology

18. Shanxi Agricultural University

19. Jinzhong

20. Institute of Biotechnology

21. Cornell University

22. Ithaca

23. USA

24. Department of Animal Science

Abstract

With a combination of bioinformatics, proteomic approaches and western blot, five potentially useful biomarkers (PI3K, AKT, mTOR, IGF and IGFBP2) related to Se deficiency induced organs damage in chicken are discovered.

Funder

National Natural Science Foundation of China

Northeast Agricultural University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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