Development of 2-deoxystreptamine–nucleobase conjugates for the inhibition of oncogenic miRNA production-Reference-Cited by-同舟云学术

Development of 2-deoxystreptamine–nucleobase conjugates for the inhibition of oncogenic miRNA production

Published:2022 Issue: Volume: Page:
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Tran Thi Phuong Anh¹,Poulet Sylvain¹,Pernak Mélanie¹,Rayar Anita¹,Azoulay Stéphane¹^ORCID,Di Giorgio Audrey¹,Duca Maria¹^ORCID

Affiliation:

1. Université Côte d'Azur, CNRS, Institut de Chimie de Nice (ICN), Nice, France

Abstract

2-deoxystreptamine (2-DOS) conjugates with artificial nucleobases were designed and synthesized to inhibit pre-miR-372 processing into oncogenic miRNA and were discovered to be promising inhibitors when compared to their neomycin counterpart.

Funder

Agence Nationale de la Recherche

Ministry of Science and Technology

Université Côte d’Azur

Association Nationale de la Recherche et de la Technologie

Sanofi Pasteur

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/MD/D1MD00345C

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