Design, synthesis and biological evaluation of novel morpholinopyrimidine-5-carbonitrile derivatives as dual PI3K/mTOR inhibitors-Reference-Cited by-同舟云学术

Design, synthesis and biological evaluation of novel morpholinopyrimidine-5-carbonitrile derivatives as dual PI3K/mTOR inhibitors

Published:2024 Issue:2 Volume:15 Page:733-752
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Rady Ghada S.¹,El Deeb Moshira A.²,Sarg Marwa T. M.²,Taher Azza T.³⁴,Helwa Amira A.⁵^ORCID

Affiliation:

1. Directorate of Health Affairs in Giza, Ministry of Health, Egypt

2. Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt

3. Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt

4. Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, October 6 University (O6U), 6th of October city, Giza 12585, Egypt

5. Department of Pharmaceutical Organic Chemistry, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology (MUST), Al-Motamayez District, P.O. Box: 77, 6th of October city, Giza, Egypt

Abstract

In this study, novel morpholinopyrimidine-5-carbonitriles were designed and synthesized as dual PI3K/mTOR inhibitors and apoptosis inducers.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D3MD00693J

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