A water-soluble fluorescent pH probe and its application for monitoring lysosomal pH changes in living cells

Author:

Zhang Lei1,Guo Jun2,You Qihua3ORCID,Xu Yuqing4

Affiliation:

1. Department of Biology, Xinzhou Teachers University, Xinzhou, Shanxi Province 034000, P. R. of China

2. ShanXi Weipu Testing Technology Co. Ltd, Taiyuan, Shanxi Province 030012, P. R. of China

3. College of Environment and Public Health, Xiamen Huaxia University, Xiamen, Fujian Province 361024, P. R. of China

4. School of Physics and Optoelectronics Engineering, Ludong University, Yantai, Shandong Province 264025, P. R. of China

Abstract

A water soluble fluorescent pH probe based on a dicyanoisophorone molecular platform has been designed. The probe could be applied for the monitoring of lysosomal pH in living cells and tracking lysosomal pH changes stimulated by chloroquine.

Funder

Xinzhou Teachers University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

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