Affiliation:
1. Centre for Molecular Informatics, Yusuf Hamied Department of Chemistry, University of Cambridge, UK
Abstract
This review summarises different data, data resources and methods for computational mechanism of action (MoA) analysis, and highlights some case studies where integration of data types and methods enabled MoA elucidation on the systems-level.
Funder
Biotechnology and Biological Sciences Research Council
AstraZeneca
Eli Lilly and Company
Publisher
Royal Society of Chemistry (RSC)
Subject
Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)
Reference248 articles.
1. Extending in silico mechanism-of-action analysis by annotating targets with pathways: application to cellular cytotoxicity readouts
2. S. W.Page and J. E.Maddison , in Small Animal Clinical Pharmacology , ed. J. E. Maddison , S. W. Page and D. B. Church , W. B. Saunders , Edinburgh , 2nd edn, 2008 , pp. 1–26
3. Stratified medicine: strategic and economic implications of combining drugs and clinical biomarkers
4. Mechanism matters , Nat. Med. , 2010 , 16 , 347
5. L.Rovin , 22 Case Studies Where Phase 2 and Phase 3 Trials Had Divergent Results , FDA
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