Anti-choline esterase activity of ceramides from the Red Sea marine sponge Mycale euplectellioides

Author:

Abdelhameed Reda12345,Elgawish Mohamed Saleh678910,Mira Amira57111210,Ibrahim Amany K.578910,Ahmed Safwat A.578910,Shimizu Kuniyoshi1314151617,Yamada Koji1234

Affiliation:

1. Graduate School of Biomedical Sciences

2. Nagasaki University

3. Nagasaki 852-8521

4. Japan

5. Pharmacognosy Department

6. Medicinal Chemistry Department

7. Faculty of Pharmacy

8. Suez Canal University

9. Ismailia 41522

10. Egypt

11. Mansoura University

12. Mansoura 35516

13. Division of Systematic Forest and Forest Products Sciences

14. Department of Agroenvironmental Sciences

15. Faculty of Agriculture

16. Graduate School of Kyushu University

17. Fukouka 812-8581

Abstract

New ceramides were isolated, and structurally elucidated, from the marine sponge Mycale euplectellioides. The isolated compounds showed moderate anti-choline esterase activity in vitro and tight binding to AChE as confirmed through a docking study.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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