An acetyltransferase controls the metabolic flux in rubromycin polyketide biosynthesis by direct modulation of redox tailoring enzymes-Reference-Cited by-同舟云学术

An acetyltransferase controls the metabolic flux in rubromycin polyketide biosynthesis by direct modulation of redox tailoring enzymes

Published:2022 Issue:24 Volume:13 Page:7157-7164
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Toplak Marina¹,Nagel Adelheid¹,Frensch Britta¹,Lechtenberg Thorsten¹,Teufel Robin²^ORCID

Affiliation:

1. Faculty of Biology, University of Freiburg, Schänzlestrasse 1, 79104 Freiburg, Germany

2. Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland

Abstract

Characterization of the acetyltransferase GrhJ reveals the surprising acetylation of flavoenzyme GrhO6 in rubromycin polyketide biosynthesis, showcasing a novel principle for the enzymatic regulation of secondary metabolic pathways.

Funder

Austrian Science Fund

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC01952C

Reference40 articles.

1. Isolation, biological activity, biosynthesis and synthetic studies towards the rubromycin family of natural products

2. Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork

3. Isolation and structure elucidation of a novel griseorhodin.

4. Biosynthesis of Pentangular Polyphenols: Deductions from the Benastatin and Griseorhodin Pathways

5. Cleavage of Four Carbon−Carbon Bonds during Biosynthesis of the Griseorhodin A Spiroketal Pharmacophore

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