Physicochemical stimuli as tuning parameters to modulate the structure and stability of nanostructured lipid carriers and release kinetics of encapsulated antileprosy drugs

Author:

Kanwar Rohini1,Gradzielski Michael2ORCID,Prevost Sylvain3ORCID,Kaur Gurpreet1ORCID,Appavou Marie-Sousai4,Mehta S. K.1ORCID

Affiliation:

1. Department of Chemistry and Centre for Advanced Studies in Chemistry, Panjab University, Chandigarh-160014, India

2. Stranski Laboratorium für Physikalische und Theoretische Chemie, Institut für Chemie, Technische Universität Berlin, D-10623 Berlin, Germany

3. Institut Max von Laue – Paul Langevin (ILL), 71 avenue des Martyrs, 38042 Grenoble, France

4. Jülich Centre for Neutron Science (JCNS) at Heinz Maier-Leibnitz Zentrum (MLZ), Forschungszentrum Jülich GmbH, Lichtenbergstr. 1, 85748 Garching, Germany

Abstract

To unveil the effect of electrolyte concentration, pH and polymer addition on Tween 80 stabilized nanostructured lipid carriers (NLCs, based on dialkyldimethylammonium bromides DxDAB and Na oleate), an in-depth scattering analysis was performed.

Funder

Council of Scientific and Industrial Research, India

Deutscher Akademischer Austauschdienst

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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