Efficacy of tyrosine kinase inhibitors examined by a combination of Raman micro-spectroscopy and a deep wavelet scattering-based multivariate analysis framework-Reference-Cited by-同舟云学术

Efficacy of tyrosine kinase inhibitors examined by a combination of Raman micro-spectroscopy and a deep wavelet scattering-based multivariate analysis framework

Published:2024 Issue:7 Volume:149 Page:2004-2015
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Schuler Irina¹²,Schuler Martin¹²^ORCID,Frick Tatjana¹²,Jimenez Dairovys¹²,Maghnouj Abdelouahid³,Hahn Stephan³,Zewail Rami⁴,Gerwert Klaus¹²^ORCID,El-Mashtoly Samir F.¹²⁵^ORCID

Affiliation:

1. Center for Protein Diagnostics, Ruhr-University Bochum, Bochum, Germany

2. Department of Biophysics, Ruhr-University Bochum, Bochum, Germany

3. Department of Molecular GI-Oncology, Clinical Research Center, Ruhr-University Bochum, Bochum, Germany

4. Department of Computer Science & Engineering, Egypt-Japan University of Science and Technology, New Borg El-Arab, Egypt

5. Biotechnology Program, Institute of Basic and Applied Science, Egypt-Japan University of Science and Technology, New Borg El-Arab, Egypt

Abstract

Raman micro-spectroscopy is applied as a label-free analytical tool to monitor the efficacy and spatial distribution of tyrosine kinase inhibitors in cells. This method has a prospective in drug evaluation and presumably in drug discovery.

Funder

Ministerium für Innovation, Wissenschaft und Forschung des Landes Nordrhein-Westfalen

Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/AN/D3AN02235H

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