A peptide-derived strategy for specifically targeting the mitochondria and ER of cancer cells: a new approach in fighting cancer

Author:

Sohn Yang Sung1ORCID,losub-Amir Anat2,Cardenas Alfredo E.3ORCID,Karmi Ola14,Yahana Merav Darash1,Gruman Tal2,Rowland Linda4,Marjault Henri-Baptiste1,Webb Lauren J.5ORCID,Mittler Ron4ORCID,Elber Ron3ORCID,Friedler Assaf2ORCID,Nechushtai Rachel1ORCID

Affiliation:

1. The Alexander Silberman Institute of Life Science, The Hebrew University of Jerusalem, Edmond J. Safra Campus at Givat Ram, Jerusalem 9190401, Israel

2. Institute of Chemistry, The Hebrew University of Jerusalem, Edmond J. Safra Campus at Givat Ram, Jerusalem 9190401, Israel

3. Institute for Computational Engineering and Science and Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, USA

4. Department of Surgery, University of Missouri School of Medicine, Christopher S. Bond Life Sciences Center University of Missouri. 1201 Rollins St, Columbia, MO 65201, USA

5. Department of Chemistry, The University of Texas at Austin, 2506 Speedway STOP A5300, Austin, TX 78712, USA

Abstract

An effective anti-cancer therapy should exclusively target cancer cells and trigger in them a broad spectrum of cell death pathways that will prevent avoidance.

Funder

United States - Israel Binational Science Foundation

Welch Foundation

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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